Ten-pass ozone therapy is a high-dose variant of major autohemotherapy (MAH). In a single session, approximately 200ml of blood is drawn, ozonated, and returned — repeated up to 10 times during the same visit. The total ozone exposure approaches what EBOO delivers but uses a different delivery mechanism. Ten-pass is a powerful tool for chronic immune dysregulation, post-viral fatigue, and select autoimmune presentations.
Ten-pass ozone therapy progressively exposes your circulating blood volume to medical-grade ozone at increasing doses across the 10 passes. The therapeutic mechanism includes upregulation of antioxidant defenses (NRF2 pathway), modulation of inflammatory cytokines, improved oxygen utilization, and immune system rebalancing. Each pass adds to the cumulative effect, with the final passes at the highest tolerated ozone concentration. Total session time is typically 90–120 minutes. Clinical applications include chronic fatigue and post-viral syndromes, Lyme and tick-borne illness recovery, autoimmune dysregulation, athletic recovery, and select cancer adjunct protocols (under separate oncology supervision). Contraindications match standard ozone therapy: G6PD deficiency, hyperthyroidism, recent stroke or MI, pregnancy, and active hemorrhage. Pre-treatment baseline labs are required for first-time patients.
Side-by-side
Ten-Pass Ozone vs EBOO vs Major Autohemotherapy
Three high-dose ozone modalities compared by delivery and total dose.
| Property | Ten-Pass | EBOO | MAH |
|---|---|---|---|
| Blood volume processed | ~200 mL × 10 = ~2,000 mL | Continuous extracorporeal circuit | ~200 mL once |
| Filtration | None | Dialysis-grade membrane | None |
| Session duration | 90–120 min | 60–90 min + IV prep | 30–45 min |
| Ozone dose pattern | Progressive escalating | Continuous high-dose | Single fixed dose |
| Equipment complexity | Moderate | Highest (dialysis circuit) | Lowest |
| Typical applications | Chronic Lyme, post-viral, autoimmune | Chronic Lyme, severe autoimmune, oncology adjunct | Wellness, immune priming |
All three modalities deliver medical-grade ozone under physician supervision with continuous monitoring.
Frequently asked
How is ten-pass different from a regular ozone treatment?
A standard major autohemotherapy (MAH) treats one bag of blood (~200ml) and returns it. Ten-pass repeats this 10 times in the same session at progressively higher ozone concentrations — the total dose approaches what EBOO delivers via a different mechanism.
How long does the session take?
90–120 minutes total. Each pass takes 8–12 minutes including the ozonation step.
Is ten-pass safer than EBOO?
Both are safe when performed by trained physicians. Ten-pass uses simpler equipment and a less complex circuit; EBOO uses continuous filtration. Risk profiles are comparable. Choice typically depends on availability, patient tolerance, and condition being addressed.
What does it feel like?
Most patients describe a warm sensation as ozonated blood returns. No major discomfort. Many feel energized for hours afterward.
How many sessions for chronic conditions?
Series of 4–10 sessions over 2–3 months for chronic Lyme, autoimmune dysregulation, or chronic fatigue, then maintenance every 1–3 months.
Research & evidence
Supporting clinical research
Peer-reviewed sources informing our protocols. We update this list as new high-quality studies are published.
- Bocci VA (2006). Scientific and Medical Aspects of Ozone Therapy: State of the Art. Archives of Medical Research. View on PubMed →
- Sagai M, Bocci V (2011). Mechanisms of Action Involved in Ozone Therapy. Medical Gas Research. View on PubMed →